Registration of MR images with a Computerized Brain Atlas

The Computerized Brain Atlas (CBA) database [8] is based on anatomical information obtained from a cryosectionned brain. It provides a meshed description of the surfaces of most brain structures, including sulci and gyri, Brodmann cytoarchitectonic areas and basal ganglia. This atlas is adjusted to individual brain images which supplies templates for sulci labelling and delineation of the Brodmann areas.
In [155], matching the CBA with an individual MRI data set is done manually by choosing the optimum parameters for a number of elementary transformations that are combined into a general 3D second degree transformation. The optimization criterion is the visual matching of the CBA objects, mainly the cortical surface and the ventricular system, super-imposed on the scan. Although the accuracy of the method has been demonstrated [142], it suffers from being both time-consuming and operator dependent.